Alzheimerdisease相关论文
牙周病是由细菌引起的牙支持组织的疾病，可导致全身的慢性低度炎症。一旦全身慢性炎症持续存在，可能诱发神经炎症。神经炎症是多种神......
核内不均一核糖核蛋白属于RNA结合蛋白中的一类，具有高度保守的结构。其中，核内不均一核糖核蛋白A2/B1(hnRNPA2/B1)参与转录、翻译等......
Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-am
Background::Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease (AD). Ho......
Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-am
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Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy bod
Neurodegenerative diseases are a class of chronic and complex disorders featuring progressive loss of neurons in distinc......
Background :Alzheimer disease is the most common cause of dementia in the elderly. Currently, no treatment is demonstrat......
Different patterns of inter-hemispheric resting-state functional connectivity among amnestic mild co
Background Amnestic mild cognitive impairment (aMCI) is recognized as the prodromal phase of Alzheimers disease (AD).Var......
Decreased Intrinsic Functional Network in Cognitively Intact Elderly APOE ε4 Carriers Measured by Ei
Background: Possession of the apolipoprotein E(APOE)ε4 allele is the best established genetic risk factor for sporadic ......
Alzheimers disease (AD) is a chronic,progressing neuronal degeneration disease,the etiology and pathogenesis of AD is no......
Behavior responses in APP/V717I transgenic mice with gender difference during AD pathology processin
Alzheimer disease(AD),one of the most common forms of dementia,is an age-dependent progressive neurodegenerative disorde......
Alzheimers disease(AD)mainly involves damage to the central nervous system,which clinical manifestation is reduced learn......
Objective: To investigate the effects of personality traits on the level of perceived stress of caregivers of Alzheimer ......
Observation study of the retina with the Alzheimer Disease and amnestic Mild Cognitive Impairment pa
Objective We investigated the regularity changes of the retinalnerve fiber layer (RNFL) and macular ganglion cell comple......
Activation of α7 nAChR by PNU improves synaptic and cognitive function through restoring the express
OBJECTIVE Alzheimer disease(AD)is the most common type of dementia and is featured by the accumulation of β-amyloid pep......
Network pharmacology-based analysis of Chinese herbal NaoDeSheng formula for application to Alzheime
OBJECTIVE To predict the potential targets and uncover the mechanisms of NaoDeSheng formula for the treatment of Alzheim......
Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length huma
A pathological hallmark of Alzheimer disease and other tauopathies is the formation of neurofibrillary tangles mainly co......
OBJECTIVE Abnormally increased production and accumulation of β-amyloid(Aβ)is the most prominent hallmark of Alzheimer......
Effects and underlying mechanisms of cannabinoid receptor 2 on neuroinflammation and cognitive perfo
OBJECTIVE The endogenous cannabinoid system has been considered as a potential therapeutic target to ameliorate neuroinf......
Modulating balance of synaptic and extrasynaptic NMDA receptors(NMDARs)shows priority over nonselect
OBJECTIVE Alzheimer disease(AD)patients suffer a disturbance in the balance between synaptic NMDARs(NR2A,mediating the p......
FFPM,a PDE4 inhibitor,recues cognitive dysfunction in APP/PS1 transgenic mice via cAMP/PKA/CREB/BDNF
OBJECTIVE In this study,we investigated the effect of FFPM,a novel PDE4 inhibitor,on learning and memory deficits as wel......
Background: Positron emission tomography (PET) has several recognized applications in neurocognitive disorders,such as d......
OBJECTIVE Alzheimer disease(AD)is the most common type of senile dementia.The anti-aging gene Klotho is reported to decl......
Physalin B reduce secretion of Aβ by inhibiting phosphorylation ofSTAT3 via down-regulated expressio
OBJECTIVE Extracellular amyloid-β(Aβ)plaques are one of the major pathological hallmarks of Alzheim-er disease(AD).The......
The most common age-related neurodegenerative disease is Alzheimer disease(AD),the imbalance between Aβ generation and ......
Alzheimer disease(AD)has now become the most common brain disorder among the older population.In addition,the currently ......
miR-125b contributes BBB and cognitive dysfunction in presenilin1/2 conditional knock-out mice throu
With the increasing average lifespan,the incidence of Alzheimers disease(AD)has an alarming rise.AD is a neurodegenerati......
Background With the developing and widely using ofelectromagnetic field (EMF),more and more studies are focusing on the ......
P08.A COMPUTATIONAL STUDY ON A HYPOTHESIS LINKING ALUMINUM FLUORIDE TO ALZHEIMER DISEASE-SEARCHING F
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Selective impairment of musical emotion recognition in patients with amnesic mild cognitive impairme
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A pilot study on the relationship between thyroid status and neuropsychiatric symptoms in patients w
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目的初步探讨5个候选基因（APH1B、PRNP、HMGCR、SIRT1、ApoE）的单核苷酸多态性（SNP）与阿尔茨海默病（AD）的关联性，同时分析BAX和ApoE基因启......
目的基于血清小分子核糖核酸（microRNA，miRNA）构建阿尔茨海默病（Alzheimer′s disease，AD）预测诊断模型。方法从高通量基因表达数据库下......
目的探索线粒体DNA（mitochondrial DNA，mtDNA）变异与早发家族性阿尔茨海默病发病风险的相关性。方法从2014年3月至2020年4月收集到的......
阿尔茨海默病（Alzheimer′s disease，AD）的病因不明，越来越多的研究表明肠道菌群与AD 的发生发展密切相关。肠道菌群通过脑-肠轴影响中......
Alzheimer disease (AD) is the most common type of dementia characterized by the progressive cognitive and social decline......
Abnormally hyperphosphorylated microtubule-associated protein tau, the major protein of the intracellular neurofibri......
Epimedium Brevicornum is a traditional Chinese medicinal plant possessing properties of sweet,warm,tonifying kidney,......
A 36-week multicenter,randomized,double-blind,placebo-controlled,parallel-group,Phase 3 clinical tri
BACKGROUND New therapies are urgently needed for Alzheimer disease(AD).Sodium oligomannate(GV-971)is a marine-derive......
Modulating balance of synaptic and extrasynaptic NMDA receptors as strategy for Alzheimer disease dr
The unbalance between synaptic(GluN2A,mediating the protective pathway)and extra-synaptic NMDA receptors(NMDARs)(Glu......
虽然阿尔茨海默病的诊断标准已经建立，但临床症状差异很大，其特殊类型额叶变异型与行为变异型额颞叶痴呆在临床症状上非常相似，这为鉴......
目的 探讨中国汉族人群中脑源性神经营养因子(BDNF)基因Val66Met单核苷酸多态性(SNP)与阿尔茨海默病(AD)的相互关系. 方法采用等位......
突触可塑性是指突触在神经元持续活动影响下发生的特异性数目、结构和功能的变化,它是学习记忆形成的基础,在神经功能中发挥重要的......
Effect of Bushenyisui Formula on brain tissue apoptosis and Bcl-2 in beta-amyloid protein-induced Al
在 Alzheimer 的疾病(广告) 的老鼠模型的大脑在房间 apoptosis 和积极 B 房间淋巴瘤(Bcl-2 ) 上调查 Bushenyisui 公式的效果的目......
目的：检测ToU样受体4（TLR4）在阿尔茨海默病（AD）及血管性痴呆（VaD）患者外周血单核细胞的表达情况．探讨TLR4在老年期痴呆发病机制中的可能作......
目的 ：分析不同剂量石杉碱甲对不同严重程度阿尔茨海默病（AD）患者的疗效。方法 ：将符合AD诊断标准的229例患者根据简易精神状态检查（MMS......
